LORZONE Tablets (2019)

Βιβλιογραφική αναφορά

Συγγραφείς

Vertical Pharmaceuticals, Inc.

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1. Description

Each 375 mg Lorzone tablet contains: chlorzoxazone USP 375 mg. Each 750 mg Lorzone tablet contains: chlorzoxazone USP 750 mg. Chemical Name: 5-Chloro-2-benzoxazolinone. Structural Formula: Molecular ...

2. Clinical Pharmacology

Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of ...

3. Indications and Usage

Lorzone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug ...

4. Contraindications

Lorzone is contraindicated in patients with known intolerance to the drug.

5. Warnings

Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing ...

6. Precautions

Lorzone should be used with caution in patients with known allergies or with a history of allergic reactions to drugs. If sensitivity reaction occurs such as urticaria, redness, or itching of the skin, ...

7. Adverse Reactions

Chlorzoxazone-containing products are usually well tolerated. It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light- ...

9. Overdosage

Symptoms Initially, gastrointestinal disturbances such as nausea, vomiting, or diarrhea together with drowsiness, dizziness, lightheadedness or headache may occur. Early in the course there may be malaise ...

10. Dosage and Administration

Usual Adult Dosage <u>Lorzone Tablets (chlorzoxazone USP) 375 mg:</u> One tablet three or four times daily. If adequate response is not obtained with this dose, the 375 mg tablets may be increased to two ...

11. How Supplied

Lorzone Tablets (chlorzoxazone USP) is supplied as follows: <u>375 mg:</u> A white capsule shaped tablet, debossed ADG on one side and 375 on the other side, in bottles of 100 tablets, NDC 68025-046-10. ...

12. Storage and Handling

Store at 20° to 25°C (68° to 77°F).